FACTOR XII DEFICIENCY - A RARE COAGULATION DISORDER
نویسندگان
چکیده
منابع مشابه
Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris. In the patient's plasma, factor XII activity and antigen levels were only 1.6% and 5.0%, respectively, of those seen in a normal subject. Immunoblot analysis showed that the secreted factor XII Tenri existed not only as a monomer (76 kD...
متن کاملCoagulation Factor XII Congenital Deficiency in Women with Recurrent Miscarriage
Factor XII (Hageman factor) is an important protease that plays a major role in the initiation of the intrinsic pathway of blood coagulation and fibrinolysis and kinin formation. It is still unclear whether factor XII deficiency causes any disorders during pregnancy. Because the main clinical feature in patients with factor XII deficiency is thrombosis rather than bleeding, low dose aspirin wou...
متن کاملFactor XII Deficiency
Factor XII ia a single-chain beta-globulin serine protease with a molecular weight of 80,000 84,000 daltons and a plasma concentration of approximately 30 pg/mL. Proteolytic cleavage of factor XII is mediated by charged surfaces (glass, kaolin, cellite, dextran sulfate, endotoxin, urates, crude collagen, sulfatides), autoactivation, and kallikrein. Prekallikrein, factor XI, factor VII, plasmino...
متن کاملCoagulation factor XII protease domain crystal structure
BACKGROUND Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI. OBJECTIVE To investigate FXII zymogen activation and substrate recognition by determining the crystal structure of the FXII protease domain. METHODS AND RESULTS A series of recombinant FXII protease constructs were characteri...
متن کاملCase Report Essential thrombocytosis accompanied by coagulation factor XII deficiency: a case report
Essential thrombocytosis (ET) is a type of myeloproliferative neoplasm with clinical manifestations of thrombosis and hemorrhage, the mechanisms of which remains unclear. Some researches indicated that ET is mainly related to the defect of platelet function and the abnormality of coagulation mechanism. A few reports showed that ET accompanied by acquired hemophilia. However, no evidence of ET w...
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ژورنال
عنوان ژورنال: Indian Journal of Child Health
سال: 2016
ISSN: 2349-6118,2349-6126
DOI: 10.32677/ijch.2016.v03.i04.020